  
  Cardiac 
  Regeneration

Treating coronary artery disease with the power of sound

The CSW Solution

CSW Therapeutics is using the power of focused soundwaves to treat refractory angina, a chronic condition in no-option coronary artery disease patients who suffer from long-lasting symptoms due to ischaemia, affecting:

2.4 million

patients in the US, Europe and Japan [1], causing:

€16.8B

in annual costs in Europe alone (~7k/patient) [2]

Using recurring & personalized focused soundwave therapy, Neowave Cardio™ use can stimulate myocardial tissue on a cellular level, inducing an angiogenic effect, leading to improved ventricular function and quality of life [3].

Our patented Neowave Cardio™ soundwave therapy device aims to:

Investigational Device. Limited by Federal (or United States) Law to Investigational Use

Product under development. Not available for commercial sale.

Restore myocardial function and quality of life in a no-option patient group

Simplify treatment delivery and reduce cost of patient management

Personalize therapy for optimal therapeutic effect

The Technology

The Neowave Cardio™ device is a next-generation acoustic therapy device, focused on ameliorating anginal symptoms and restoring cardiac function in ischemic heart disease patients.

By employing therapeutic low-intensity acoustic soundwaves, the device aims to catalyze angiogenesis—the natural process of new blood vessel formation—to enhance circulatory function. Cardiac shockwave therapy has been validated in more than 50 studies [4] to:

Reduce angina symptoms
Enhance left ventricular function
Improve exercise capacity and tolerance

By miniaturizing and personalizing therapy, CSW Therapeutics aims to better treatment efficacy and therapy compliance, while improving access to care & reducing costs.

NeoWave Cardio™ soundwave therapy device

Assessment of patient safety and personalized therapy

Adjustable form factor for optimal therapy

Personalized and targeted therapy

Cardiac Extracorporeal Soundwave Therapy utilizes low-intensity acoustic soundwaves, functioning as gentle “wake-up calls” to propel the body’s inherent healing processes. These soundwaves induce a mechanical disturbance within the cells, much like a tap on the shoulder, encouraging cellular activation.

  
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About 
  the Treatment

These cells release specific signaling molecules and initiate internal repair mechanisms, beginning a process known as mechanotransduction, where mechanical inputs are converted into biological reactions.

This cellular activity leads to angiogenesis, reduced inflammation, and enhanced tissue healing [5], through the activation of the body’s natural physiological responses.

Rentrop Score shows the formation of collateral vessels: Grade 0 no collaterals; grade 1 side branch filling of the recipient artery without filling of the main epicardial artery; grade 2 partial filling of the main epicardial recipent artery; and grade 3 complete filling of the main epicardial recipient artery [6 ].